Blood vessels hold key to thicker hair growth

Blood vessels hold key to thicker hair growth

Boston February 14, 2001 Researchers at Massachusetts General Hospital (MGH) have been able to grow hair faster and thicker on mice thanks to a protein that promotes blood vessel growth in their skin. The mouse hair follicles while no greater in number than those of normal mice are individually bigger. Collectively, they increase the total volume of hair by 70 percent the MGH research team reports in the Feb. 19 Journal of Clinical Investigation. If the protein has the same powers
in humans, it could lead to the first angiogenic therapy for male pattern baldness. “In male pattern hair loss, it’s not that the follicles are gone. “If anyone could find a way to make the follicles bigger, men might grow hair again. ”

The discovery that increasing blood flow to the scalp helps stave off baldness may be old news to many barbers. For years, they have been advising clients to massage their scalps as way of
prednisone online overnight , cheapest prednisone uk, prescription prednisone , online pharmacy no prescription overnight shipping  stimulating circulation and hair growth. A few scientific studies have suggested that people with hair loss may have fewer blood vessels. But no one had actually measured how closely blood vessel growth is correlated with hair growth, or what might cause scalp vessels to grow in the first place. Avid studio raising the bar for mobile video editing ipad. To explore these questions, Kiichiro Yano, a research associate in dermatology at MGH, and his colleagues compared two groups of mice, one normal and one genetically programmed to produce an abundance of a protein known to trigger blood vessel growth, VEGF. The VEGF enhanced mice grew hair faster and thicker in the first two weeks of life than did the control mice. The VEGF enhanced mice also regrew hair faster. Shaved 8 week old VEGF mice not only grew hair back sooner, they exhibited a 30 percent increase in hair follicle diameter 12 days after depilation. “By overall volume, the hair was about 70 percent thicker than in wild type mice,” says Detmar. Blood vessels located in the skin surrounding the pumped up hair follicles were 40% larger in diameter than those found in normal mice, suggesting that the VEGF mediated angiogenesis was causing the hair to grow faster and thicker. When normal mice were treated with an antibody that blocks VEGF activity and then shaved, their hair grew back slower and was thinner than their untreated littermates. Twelve days after depilation, the VEGF deprived mice still displayed bald spots and overall reduced hair growth. “So by modulating VEGF, we can directly influence the size of the hair,” says Detmar. As for how the VEGF inspired blood vessels are plumping up the hair shafts, the researchers believe they may be delivering an extra supply of growth factors, in addition to oxygen and nutrients. Detmar and his colleagues are developing a technique to deliver VEGF topically to the scalp. “The question now is can we, by this method, improve hair growth in humans,” he says. “Applying it to humans will be the big challenge. “Lawrence F. The Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital
based research program in
the United States, with an annual research budget of more than $200 million and major research centers in AIDS, the neurosciences, cardiovascular research, cancer, cutaneous biology, transplantation biology and photo medicine. In 1994, the MGH joined with Brigham and Women’s Hospital to form Partners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups and nonacute and home health services. The state’s newly redesigned assessments will be administered to nearly every student in http://essaysreasy.online/ reading, writing, and math in , and 10

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